Abstract
A new class of O-arylmandelic acid PPAR agonists show excellent anti-hyperglycemic efficacy in a db/db mouse model of DM2. These PPARalpha-weighted agonists do not show the typical PPARgamma associated side effects of BAT proliferation and cardiac hypertrophy in a rat tolerability assay.
MeSH terms
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Animals
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Mandelic Acids / metabolism
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Mandelic Acids / pharmacology*
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Mice
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Mice, Inbred C57BL
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Mice, Transgenic
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Protein Binding / drug effects
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Protein Binding / physiology
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Rats
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Receptors, Cytoplasmic and Nuclear / agonists*
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Receptors, Cytoplasmic and Nuclear / metabolism
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Transcription Factors / agonists*
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Transcription Factors / metabolism
Substances
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Mandelic Acids
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Receptors, Cytoplasmic and Nuclear
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Transcription Factors